腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)重組蛋白
Recombinant Brain Derived Neurotrophic Factor (BDNF)
Neurotrophin; Abrineurin
- 編號(hào)URPA011Gu01
- 物種Cavia (Guinea pig ，豚鼠) 相同的名稱，不同的物種。
- 來源原核表達(dá)
- 宿主E.coli
- 內(nèi)毒素水平<1.0EU/µg(LAL法測(cè)定)
- 亞細(xì)胞定位分泌
- 預(yù)測(cè)分子量41.6kDa
- 實(shí)際分子量44kDa(差異分析請(qǐng)參閱說明書)
- 片段與標(biāo)簽Ser147~Leu249 with N-terminal His and GST Tag
- 緩沖液成份PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
- 性狀凍干粉
- 純度> 95%
- 等電點(diǎn)9.3
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應(yīng)用
Positive Control; Immunogen; SDS-PAGE; WB.
如果需要有生物活性的蛋白，請(qǐng)參見活性蛋白。 - 下載 英文說明書 中文說明書
- 規(guī)格 10μg50μg 200μg 1mg 5mg
- 價(jià)格 ¥ 588 ¥ 1470 ¥ 2940 ¥ 8820 ¥ 22050
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產(chǎn)品包裝(模擬)
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產(chǎn)品包裝(模擬)
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SDS-PAGE圖
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通過ISO 9001、ISO 13485質(zhì)量體系認(rèn)證
序列
用法
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
儲(chǔ)存
避免反復(fù)凍融。2-8°C不超過一個(gè)月，-80°C不超過12個(gè)月。
穩(wěn)定性
熱穩(wěn)定性以損失率顯示。損失率是由加速降解試驗(yàn)決定，具體方法如下：在37°C孵育48小時(shí)，沒有顯著的降解或者沉淀產(chǎn)生。保質(zhì)期內(nèi)，在適當(dāng)?shù)臈l件下存儲(chǔ)，損失率低于5%。
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相關(guān)產(chǎn)品
| 編號(hào) | 適用物種：Cavia (Guinea pig ，豚鼠) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| URPA011Gu01 | 腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UPAA011Gu01 | 腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)多克隆抗體 | WB; IHC; ICC; IP. |
| UMAA011Gu21 | 腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)單克隆抗體 | WB; IHC; ICC; IP. |
| USEA011Gu | 腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| ULMA011Gu | 腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)等多因子檢測(cè)試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
參考文獻(xiàn)
| 雜志 | 參考文獻(xiàn) |
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| J Chem Neuroanat. | Both secreted and the cellular levels of BDNF attenuated due to tau hyperphosphorylation in primary cultures of cortical neurons. [pubmed:27914953] |
| Int Immunopharmacol. | PPARr activation ameliorates postoperative cognitive decline probably through suppressing hippocampal neuroinflammation in aged mice. [pubmed:27940378] |
| The Journal of Maternal-Fetal & Neonatal Medicine | Differential expression of cord blood neurotrophins in gestational diabetes: the impact of fetal growth abnormalities [pubmed:28081639] |
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| Bipolar Disorders | Long‐term lithium treatment increases intracellular and extracellular brain‐derived neurotrophic factor (BDNF) in cortical and hippocampal neurons at subtherapeutic … [bdi.12449] |
| Elsevier | Associations of blood parameters with age, feed efficiency and sampling routine in young beef bulls [science:article] |
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| American Journal of Translational Research | A new comorbidity model and the common pathological mechanisms of migraine and epilepsy [pubmed:28559979] |
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| Experimental Neurology | Preterm umbilical cord blood derived mesenchymal stem/stromal cells protect preterm white matter brain development against hypoxia-ischemia [Pubmed:30012511] |
| Nutrients | Early Life Vitamin C Deficiency Does Not Alter Morphology of Hippocampal CA1 Pyramidal Neurons or Markers of Synaptic Plasticity in a Guinea Pig Model. [Pubmed:29890692] |
| Neurotoxicity Research | Delta-9-Tetrahydrocannabinol (?-THC) Induce Neurogenesis and Improve Cognitive Performances of Male Sprague Dawley Rats [Pubmed:28933048] |
| Neurotoxicology | Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats [Pubmed:29522778] |
| Neuroscience Letters | Long term Westernized diet leads to region-specific changes in brain signaling mechanisms [Pubmed:29655945] |
| Applied?Physiology Nutrition and Metabolism | Changes in exercise capacity and serum BDNF following long-term sprint interval training in well-trained cyclists [Pubmed: 30286300] |
| Heliyon | Establishment and evaluation of a novel mouse model of peri/postmenopausal depression [Doi: 10.1016/j.heliyon.2019.e01195] |
| BioMed Research International | Administration of Repetitive Transcranial Magnetic Stimulation Attenuates Aβ1-42-Induced Alzheimer's Disease in Mice by Activating β-Catenin Signaling [] |
| International Journal of Immunopathology and Pharmacology | Effect of voluntary running on expression of myokines in brains of rats with depression [Pubmed: 30834799] |
| American Journal of Emergency?Medicine | Clinical usefulness of brain-derived neurotrophic factor and visinin-like protein-1 in early diagnostic tests for acute stroke [Pubmed: 30826210] |
| Neurochemistry International | Monoaminergic system is implicated in the antidepressant-like effect of hyperoside and protocatechuic acid isolated from Impatiens glandulifera Royle in mice [Pubmed: 31077758] |
| REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | Physical Exercise Increased Brain-Derived Neurotrophic Factor in Elderly Population with Depression [Pubmed: 30994834] |
| Journal of Alzheimer's Disease | Regular Exercise Enhances Cognitive Function and Intracephalic GLUT Expression in Alzheimer's Disease Model Mice [Pubmed: 31561359] |
| Biological Trace Element Research | Cognitive Decline of Rats with Chronic Fluorosis Is Associated with Alterations in Hippocampal Calpain Signaling [Pubmed: 31797207] |
| Psychopharmacology | Chronic harmine treatment has a delayed effect on mobility in control and socially defeated rats [Pubmed: 32088835] |
| Experimental and Therapeutic Medicine | Involvement of neurotrophic signaling in doxorubicin?induced cardiotoxicity [Pubmed: 32010279] |
| Journal of Critical Care | Association of neuronal repair biomarkers with delirium among survivors of critical illness [Pubmed: 31896448] |
| Journal of Clinical Neuroscience | CSF levels of a set of neurotrophic factors (brain-derived neurotrophic factor, nerve growth factor) and neuropeptides (neuropeptide Y, galanin) in epileptic children [Pubmed: 32327377] |
| MOLECULAR NUTRITION & FOOD RESEARCH | Hyperlipidemia Down‐Regulate Brain Antioxidant Defense Enzymes and Neurotrophins in Rats: Assessment of the Modulatory Potential of EPA+ DHA and?… [Pubmed: 32918393] |
| Neuropharmacology | Impaired LTD-like motor cortical plasticity in female patients with major depression disorder [Pubmed: 32791084] |
| COLLOIDS AND SURFACES B-BIOINTERFACES | Effects of gold nanoparticles administration through behavioral and oxidative parameters in animal model of parkinson's disease [Pubmed: 32777662] |
| Neurotoxicology | Involvement of hippocampal agmatine in β1-42 amyloid induced memory impairment, neuroinflammation and BDNF signaling disruption in mice [Pubmed: 32522471] |
| Journal of Veterinary Behavior | Comparison of serum brain-derived neurotrophic factor (BDNF) in dogs with and without separation anxiety [] |
| Food & Function | Nicotinamide riboside alleviates alcohol-induced depression-like behaviours in C57BL/6J mice by altering the intestinal microbiota associated with microglial?… [] |
| Short-but no long-term effect of social stress in rodent depressive-like behavior is not affected by chronic treatment with Harmine [] | |
| bioinformatics and biomedical engineering | Blood Plasma Trophic Growth Factors Predict the Outcome in Patients with Acute Ischemic Stroke [] |
| Overektomize di?i s??anlarda beyin oksidatif stres, bdnf ve inflamatuar cevap düzeyleri ile n?rodavran??sal de?i?iklikler üzerine anjiyotensin II ?nhibisyonunun etkisi [] | |
| EUROPEAN CHILD & ADOLESCENT PSYCHIATRY | Increased serum brain-derived neurotrophic factor and adrenocorticotropic hormone levels are associated with obsessive compulsive disorder in medication?free??- [33389158] |
| BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | Sea urchin gangliosides exhibit neuritogenic effects in neuronal PC12 cells via TrkA- and TrkB-related pathways [33589896] |
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| Einstein (Sao Paulo) | Tropomyosin receptor kinase B-mediated signaling in integration of neuropathic pain and obesity in diabetic polyneuropathy [34586159] |
| Metab Brain Dis | Moderate-intensity continuous training and high-intensity interval training improve cognition, and BDNF levels of middle-aged overweight men [34762211] |
| Transl Psychiatry | Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression [34824208] |
| Iranian Journal of Basic Medical Sciences | Adrenomedullin increases cAMP accumulation and BDNF expression in rat DRG and spinal motor neurons [34712429] |
| J Sex Med | Endogenous Deficiency of Brain-Derived Neurotrophic Factor Induces the Downregulation of Tryptophan Hydroxylase-2 Expression in Raphe Nuclei of Rapid?… [34384732] |
| Cell Biochem Funct | CNTs‐CaP/chitosan‐coated AZ91D magnesium alloy extract promoted rat dorsal root ganglia neuron growth via activating ERK signalling pathway [34296452] |
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| Clinical Rheumatology | Gender influence on clinical manifestations, depressive symptoms and brain-derived neurotrophic factor (BDNF) serum levels in patients affected by?… [Pubmed:35344113] |
| Sci Rep | Associations between serum levels of brain-derived neurotrophic factor, corticotropin releasing hormone and mental distress in vitiligo patients [Pubmed:35508633] |
| Pharmaceutics | Co-Delivery of Docosahexaenoic Acid and Brain-Derived Neurotropic Factor from Electrospun Aligned Core–Shell Fibrous Membranes in Treatment of Spinal Cord?… [Pubmed:35214053] |
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| Journal of Complementary Medicine Research | Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder [] |
| AFRICAN JOURNAL OF BIOCHEMISTRY RESEARCH | Medicinal effects of Saffron on obese animals by reducing Castellis risk index to protect from cardio-pathology and psychological distress [] |
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